Two Sides of One Dosage | Fossa Method

Two Sides of One Dosage

The “perception loop” of medications:
enthusiasm → widespread use → side effects → fear and rejection → rational balance.
It’s time to move on to the final stage…

Medications as a Lifeline

  • Methylene Blue

    • Antiseptic and mild detoxifier.
    • Supports tissue recovery and oxygen balance.
    • Useful for diagnostics and treating fry.

    Methylene blue is one of the safest and most accessible dyes in fishkeeping.
    It helps in cases of nitrite poisoning, improves tissue oxygenation, and acts as a general antiseptic.
    Used for treating fungal infections on eggs, for short baths, and diagnostic staining.
    Easy to prepare, easy to use — even for delicate or juvenile fish.

  • Formalin

    • Still effective against Cryptocaryon, Ichthyophthirius, and monogeneans.
    • Works on early stages and external parasites.
    • Included in quarantine protocols in research and public aquaria.

    Formalin (formaldehyde solution) remains a potent antiparasitic.
    It can be used in short baths, dips, or system-wide treatments.
    Penetrates mucus layers and damages cyst walls.
    Often combined with malachite and methylene blue in FMC protocols.

  • Malachite Green

    • Powerful antifungal and antiparasitic.
    • Effective even in low concentrations.
    • Fast results, easy visual feedback.

    Malachite green oxalate is highly effective against Ichthyophthirius, Saprolegnia, Trichodina, and other ectoparasites.
    Used in baths, dips, or low-dose long-term exposure.
    Despite being a synthetic dye, it has remained in use for decades due to consistent performance.
    Especially helpful in emergency outbreaks or egg disinfection.

  • FMC (Formalin + Malachite + Methylene Blue)

    • A historic “golden mix” — each component targets a different threat.
    • Simple to use, low-cost, highly visible effect.
    • Popular for general parasite prevention or in early-stage treatment.

    Once seen as an all-purpose solution, FMC became a ritual in fish medicine.
    Its popularity stemmed from simplicity, not always from evidence.

  • Antibiotics

    • Can stop systemic infections.
    • Life-saving in advanced septicemia or gill diseases.

    When used correctly, antibiotics like oxytetracycline, erythromycin, or nitrofurans help treat bacterial infections: Aeromonas, Pseudomonas, Mycobacterium spp.
    Proper dosing, good water quality, and follow-up care are key.
    Without antibiotics, fish often die en masse in infected tanks.
    Controlled use can restore populations in both private and public systems.

REFERENCES

  1. Lindholm‐Lehto P., Pylkkö P. Saprolegniosis in aquaculture and how to control it? // Aquac. Fish Fish. 2024. Vol. 4.
  2. Mooney A. Malachite Green found in Shrimp exports from Bangladesh [Electronic resource] // Randox Food. 2023. URL: https://mta-sts.randoxfood.com/malachite-green-found-in-shrimp-exports-from-bangladesh/ (accessed: 04.07.2025).
  3. Transcriptome analysis of zebra fish (Danio rerio) eggs following treatment with malachite green // Aquaculture. Elsevier, 2020. Vol. 514. P. 734500.
  4. Srivastav A. Malachite green (Triarylmethane dye) and Pyceze (Bronopol) induced histopathological and biochemical changes in the liver of a catfish Heteropneustes fossilis (Bloch.) // Indian J. Fish. 2016. Vol. 63. P. 135–139.
  5. Rao V., Ajith Kumar T.T., Badhul H. Diseases in the Aquarium Fishes: Challenges and areas of concern. // Int. J. Environ. 2013. Vol. 2.
  6. Sudova E. et al. Negative effects of malachite green and possibilities of its replacement in the treatment of fish eggs and fish: a review // Veterinární Medicína. Veterinární medicína, 2007. Vol. 52, № 12. P. 527–539.
  7. Srivastava S., Sinha R., Roy D. Toxicological effects of malachite green // Aquat. Toxicol. Amst. Neth. 2004. Vol. 66, № 3. P. 319–329.
  8. Saglam N., Ispir U., Yonar M. The Effect of Therapeutic Bath of Malachite Green on Some Haematological Parameters of Rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) // Fresenius Environ. Bull. 2003.
  9. Campbell R.E. et al. In vitro screening of novel treatments for Aphanomyces invadans // Aquac. Res. 2001. Vol. 32, № 3. P. 223–233.
  10. Culp S.J., Beland F.A. Malachite Green: A Toxicological Review // J. Am. Coll. Toxicol. SAGE Publications, 1996. Vol. 15, № 3. P. 219–238.
  11. Bly J. et al. Therapeutic and prophylactic measures for winter saprolegniosis in channel catfish // Dis. Aquat. Organ. Inter-Research Science Center, 1996. Vol. 24. P. 25–33.